Description

Glow Blend is a synergistic peptide complex designed for science-driven support of skin, connective tissue, and overall recovery. It combines three extensively studied regenerative peptides—BPC-157, TB-500 (a thymosin β4-derived peptide), and GHK-Cu—each acting on complementary pathways involved in inflammation, tissue repair, and extracellular-matrix (ECM) remodeling [1–3].

Key Highlights

• Multi-pathway tissue support: Angiogenesis, ECM rebuilding, and inflammation resolution targeted from different angles. [1, 7]
• Skin & connective tissue focus: Collagen, elastin, glycosaminoglycans, and growth-factor signaling pathways supported in vitro, in animal models, and small human series. [9, 10]
• Inflammation modulation: BPC-157 and TB-500 engage nitric-oxide and pro-resolving inflammatory pathways, while GHK-Cu supports antioxidant and copper-dependent enzyme systems. [2]

1. BPC-157 – Vascular & Connective-Tissue Support

Overview & Biochemistry

BPC-157 is a synthetic 15-amino-acid fragment of the natural Body Protection Compound from gastric juice [1].

Mechanisms of Action

• Nitric-oxide modulation: Helps rebalance NO production and activate heme oxygenase-1 and other antioxidant defenses [4].
• Angiogenesis support: Promotes new microvessel formation and stabilizes vascular integrity [5].
• Fibroblast and ECM activation: Stimulates tendon fibroblast growth and collagen organization [9].

Anti-Inflammatory & Tissue Repair Effects

BPC-157 accelerates soft-tissue and tendon healing and reduces inflammatory damage via NO-linked pathways [4, 5, 13]. Orthopaedic literature notes potential benefits in muscle, tendon, and ligament repair [1].

Anti-Aging Context

Acts as a cyto- and vasculo-protective peptide, preserving microcirculation and cellular viability in models of chronic injury [12].

2. TB-500 (Thymosin β4 Fragment) – Cell Migration & Matrix RemodelingRemove product image

Derived from the 43-amino-acid thymosin β4 (Tβ4), TB-500 mimics key domains responsible for cell motility and tissue regeneration [2, 14].

Biochemistry & Core Pathways

• Actin binding: Regulates cytoskeletal dynamics for fibroblast and endothelial migration [8].
• Angiogenic signaling: Up-regulates VEGF and bFGF, supporting neovascular formation [6].
• Matrix remodeling: Modulates myofibroblast differentiation and collagen organization [10].

Anti-Inflammatory & Repair Actions

Accelerates dermal and ocular healing while down-regulating excessive immune responses and fibrotic pathways [2, 6, 12].

Anti-Aging Context

Supports microvascular health and tissue oxygenation that may translate into healthier skin architecture [6].

3. GHK-Cu – Copper Tripeptide for Skin Remodeling & Antioxidant Defense

A naturally occurring tripeptide complex (glycyl-L-histidyl-L-lysine–Cu²⁺) found in human plasma and wound fluid [3].

Molecular Actions

• Gene regulation: Modulates expression of collagen, elastin, and antioxidant enzymes [15].
• ECM synthesis: Stimulates fibroblast activity and balances MMP/TIMP ratios [1, 3].
• Copper delivery: Provides bioavailable Cu²⁺ for enzymes like lysyl oxidase [7].

Repair & Anti-Inflammatory Benefits

Enhances wound closure and granulation in diabetic and aged models and reduces oxidative stress during inflammation [7, 17, 19].

Anti-Aging Context

Improves skin firmness and elasticity via collagen/elastin support and reduced ROS burden [9, 10].

Synergistic Benefits of Glow Blend

Responsible Use & Disclaimers: These peptides remain under research and are not approved for medical use in humans. Evidence derives mostly from animal and in vitro studies [1, 4, 15].

References

1. Józwiak M. Multifunctionality and Possible Medical Application of the BPC 157 Peptide. Pharmaceuticals (2025).
2. Sikiric P. Stable Gastric Pentadecapeptide BPC 157 as a Therapy for Vascular and Organ Damage. Pharmaceuticals (2025).
3. Tang Y. Peptides in Cosmetics: From Pharmaceutical Agents to Cosmeceuticals. Cosmetics (2025).
4. Sikiric P. BPC 157 Interacts with Nitric-Oxide System to Promote Healing. Frontiers in Pharmacology (2024).
5. Chang C. Effect of Pentadecapeptide BPC 157 on Tendon Fibroblast Growth. J. Orthop. Res. (2011).
6. Maar K. Thymosin Beta-4 Modulates Cardiac Remodeling and Connective Tissue. Int. J. Mol. Sci. (2025).
7. Wang H. Neglected Role of Copper Ions in Wound Healing. Biometals / Mater. Today Adv. (2021).
8. Xing Y. Progress on Thymosin β4 Functions and Applications. Frontiers in Endocrinology (2021).
9. He X. Research Progress on Bioactive Factors Against Skin Aging. J. Cosmetic Dermatology (2024).
10. Siméon A. GHK-Cu During Wound Healing: Modulation of Matrix Components. J. Invest. Dermatol. (2000).
11. Maar K. Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4. Cells (2021).
12. Vasireddi N. Emerging Use of BPC-157 in Orthopaedic Sports Medicine. PMCID: PMC12313605 (2025).
13. Sikiric P. BPC-157 Protects Vascular Endothelium in Organ Damage Models. Frontiers in Physiology (2024).
14. Maar K. Thymosin β4 and Connective-Tissue Regeneration Pathways. MDPI Cells (2025).
15. He X. Bioactive Peptides and Copper Complexes in Skin Aging. Frontiers in Pharmacology (2024).
16. Sosne G. Thymosin Beta-4 as Adjunct Treatment for Inflammatory Ocular Conditions. Immunology Letters (2023).
17. Tang Y. Copper-Peptide Hydrogel Promotes VEGF and bFGF Release for Tissue Repair. Frontiers in Bioengineering & Biotechnology (2024).